| Name |
let-7g
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
umbilical vein endothelial
|
| Experiment Method |
RT-qPCR,Western blot,Senescence-associated B-galactosidase (SA-B-gal) assay
|
| Up/Down |
Down
|
| Pro/Anti |
anti
|
| Funtion Description |
In Ang II-treated HUVECs with LOX-1 knockdown, let-7g still reduced the expression of IGF1, IGF1R and B-gal but increased the SIRT1 expression. Furthermore, using the SA-B-gal staining as an aging indicator, the anti-aging effect of let-7g via a LOX-1-ind
|
| Regulation Gene |
SIRT1
|
| Year |
2018
|
| Pubmed ID |
29393358
|
| Title |
MicroRNA let-7g inhibits angiotensin II-induced endothelial senescence via the LOX-1-independent mechanism.
|
| Drug |
NA
|
| Disease |
atherosclerosis
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|