Details
| Name | miR-106b cluster |
| Type | miRNA |
| Species | Homo sapiens |
| Tissue | breast |
| Experiment Method | SA B-galactosidase,qPCR |
| Up/Down | Up |
| Pro/Anti | anti |
| Funtion Description | All three miRs in this cluster target EP300, a transcriptional activator of E-cadherin, resulting in cells acquiring a phenotype characteristic of cells undergoing epithelial-to-mesenchymal transition (EMT), including an increase in both cell motility and |
| Regulation Gene | EP300 |
| Year | 2014 |
| Pubmed ID | 24270410 |
| Title | The miR-106b~25 cluster promotes bypass of doxorubicin-induced senescence and increase in motility and invasion by targeting the E-cadherin transcriptional activator EP300. |
| Drug | doxorubicin |
| Disease | breast cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |