| Name |
miR-10a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
bone
|
| Experiment Method |
Senescence-activated B-galactosidase (SA-B-gal) staining,qRT-PCR,Microarray,Western blot,Luciferase reporter assay
|
| Up/Down |
NA
|
| Pro/Anti |
anti
|
| Funtion Description |
Lentiviral constructs were used to up- or downregulate miR-10a in young and old hMSCs. Upregulation of miR-10a resulted in increased differentiation to adipogenic, osteogenic, and chondrogenic lineages and in reduced cell senescence. Conversely, downregul
|
| Regulation Gene |
KLF4
|
| Year |
2013
|
| Pubmed ID |
23696417
|
| Title |
miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|