A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name miR-124
Type miRNA
Species Mus musculus
Tissue NA
Experiment Method qRT-PCR
Up/Down Down
Pro/Anti Anti
Funtion Description WS is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN ortholog exhibit many phenotypic features of WS, including a pro-oxidant status and a shorter mean life span.Caenorhabditis elega
Regulation Gene NA
Year 2012
Pubmed ID 23075628
Title Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA