Details
| Name | miR-128a |
| Type | miRNA |
| Species | Homo sapiens |
| Tissue | NCF-CCD-18; NCM; HCT-117 |
| Experiment Method | RT-PCR,Western Blot |
| Up/Down | Up |
| Pro/Anti | NA |
| Funtion Description | Irinotecan (CPT-12) is topoisomerase I inhibitor used in the treatment of disseminated colorectal cancer. In colon cancer cells it induces DNA damage which leads to cytotoxicity with ensuing apoptosis or premature senescence. Epithelial cells upregulatede |
| Regulation Gene | NA |
| Year | 2012 |
| Pubmed ID | 22898888 |
| Title | Irinotecan induces senescence and apoptosis in colonic cells in vitro Emil Rudolf , Stanislav John, Miroslav Cervinka |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |