| Name |
miR-143-5p
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
IVD
|
| Experiment Method |
RT-qPCR,Dual luciferase reporter gene assay,Western blot,MTT,Senescence-associated B-galactosidase (SA-B-gal) staining
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
The restoration of miR-143-5p or the activation of AMPK signaling pathway decreased COL2, ACAN, and DCN expression, coupled with the inhibition of NP cell proliferation and differentiation, and promotion of NP apoptosis and senescence.
|
| Regulation Gene |
eEF2
|
| Year |
2019
|
| Pubmed ID |
30987676
|
| Title |
MicroRNA-143-5p targeting eEF2 gene mediates intervertebral disc degeneration through the AMPK signaling pathway.
|
| Drug |
NA
|
| Disease |
IDD
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|