| Name |
miR-145
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
Human urothelium
|
| Experiment Method |
Quantitative RT-PCR,Senescence-associated B-galactosidase (SA-B-gal) assay,TUNEL
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Results indicate that miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation. We propose that miR-145 may confer stem cell-like properties on urothelial carcinoma cells and thus
|
| Regulation Gene |
syndecan-1
|
| Year |
2015
|
| Pubmed ID |
26514209
|
| Title |
microRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1.
|
| Drug |
NA
|
| Disease |
prostate cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|