| Name |
miR-146a
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
bone
|
| Experiment Method |
Quantitative RT-PCR,Microarray,Senescence-Associated B-galactosidase staining,Immunofluorescence Staining,Western Blotting
|
| Up/Down |
Up
|
| Pro/Anti |
anti
|
| Funtion Description |
1) miR-146a regulates lin BMC senescence and apoptosis by suppressing Plk2 expression that, in turn, activates p16Ink4a/p19Arf and p53; and 2) modulation of miR-146a or its target Plk2 may represent a potential therapeutic intervention to improve lin BMC-
|
| Regulation Gene |
Plk2
|
| Year |
2017
|
| Pubmed ID |
27908889
|
| Title |
MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|