| Name |
miR-146a
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
eye
|
| Experiment Method |
RNA isolation and qRT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
Elevation of miR-146a and miR-146b in the aging RPE/choroid but not neuroretina suggests a role for miRNAs in inflammaging in the RPE/choroid. miR-146a overexpression inhibits the expression IL-6 and VEGF-A in the RPE cells, supporting a negative feedback
|
| Regulation Gene |
null
|
| Year |
2016
|
| Pubmed ID |
27917303
|
| Title |
miR-146a is upregulated during retinal pigment epithelium (RPE)/choroid aging in mice and represses IL-6 and VEGF-A expression in RPE cells
|
| Drug |
NA
|
| Disease |
age-related macular degeneration
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|