| Name |
miR-146a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
skin
|
| Experiment Method |
Microarray,RNA isolation and quantitative real-time PCR,Luciferase reporter assay,Western Blot,
|
| Up/Down |
Up
|
| Pro/Anti |
anti
|
| Funtion Description |
As the common miRNA regulated by UVA and UVB, miR-146a functions was investigated and miR-146a could antagonize UVA irradiation-induced photoaging. Further studies showed that UVA-upregulated Smad4 expression was suppressed by miR-146a. The results of thi
|
| Regulation Gene |
Smad4
|
| Year |
2013
|
| Pubmed ID |
23832538
|
| Title |
Differential miRNA profile on photoaged primary human fibroblasts irradiated with ultraviolet A.
|
| Drug |
NA
|
| Disease |
skin aging
|
| Environment Factors |
long-wave ultraviolet (UVA)
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|