| Name |
miR-15b
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
skin
|
| Experiment Method |
quantitative real-time PCR,SASP,Immunofluorescence and confocal laser scanning microscopy
|
| Up/Down |
Down
|
| Pro/Anti |
anti
|
| Funtion Description |
Interestingly, in all models of cellular senescence and in photoaged skin, upregulation of SIRT4 expression was associated with decreased levels of miR-15b. The latter was causally linked to increased SIRT4 expression because miR-15b targets a functional
|
| Regulation Gene |
SIRT4
|
| Year |
2016
|
| Pubmed ID |
26959556
|
| Title |
MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4.
|
| Drug |
NA
|
| Disease |
Extrinsic skin aging
|
| Environment Factors |
ultraviolet (UV),Ionizing r-irradiation (rIR)
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|