| Name |
miR-17-3p
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
heart
|
| Experiment Method |
Western blot,Real-time PCR,Senescence B-Galactosidase staining,IHC,Immunoprecipitation assay,ChIP
|
| Up/Down |
NA
|
| Pro/Anti |
anti
|
| Funtion Description |
Repression of Par4 by miR-17-3p enhanced transcriptional activity of CEBPB and FAK, which promoted mouse cardiac fibroblast (MCF) epithelial-mesenchymal transition (EMT) and self-renewal, resulting in cellular senescence and apoptosis-resistance.
|
| Regulation Gene |
Par4
|
| Year |
2015
|
| Pubmed ID |
25472717
|
| Title |
The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|