A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name miR-18
Type miRNA
Species Mus musculus
Tissue Hearts
Experiment Method RT-PCR
Up/Down Down
Pro/Anti NA
Funtion Description In aging-associated heart failure, we linked an aging-induced increase in the ECM proteins CTGF and TSP-1 to a decreased expression of their targeting microRNAs 18a, 19a, and 19b, all members of the miR-17-92 cluster. Failure-resistant mice showed an oppo
Regulation Gene NA
Year 2011
Pubmed ID 21501375
Title MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure
Drug NA
Disease HF
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA