| Name |
miR-181a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
uterus
|
| Experiment Method |
Quantitative real-time RT-PCR,Western blotting,Senescence-associated B-Gal staining,luciferase reporter assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
miR-181a is recognized as a senescence-associated miRNA and is modulated by ROS and highly expressed in senescent cells . miRNA expression profiling revealed continuous changes in the expression of miR-181a during the whole senescence process. Importantly
|
| Regulation Gene |
Akt3
|
| Year |
2018
|
| Pubmed ID |
30097674
|
| Title |
Oxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma
|
| Drug |
H2O2
|
| Disease |
uterine leiomyoma
|
| Environment Factors |
oxidation
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|