| Name |
miR-181a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
Real-time RT-PCR,Western blot,SA-B-gal staining
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Our studies demonstrated that HCV-induced up-regulation of delta Np63 leads to a decline of miR-181a, resulting in an overexpression of Sirt1 and DUSP6, and thus T cell senescence and viral persistence.
|
| Regulation Gene |
Sirt1
|
| Year |
2017
|
| Pubmed ID |
27354409
|
| Title |
Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via delta Np63-miR-181a-Sirt1 pathway.
|
| Drug |
HCV
|
| Disease |
T cell dysfunction
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|