| Name |
miR-186
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
qRT-PCR,Luciferase reporter assay,Western blot
|
| Up/Down |
Down
|
| Pro/Anti |
NA
|
| Funtion Description |
Importantly, miR-186 overexpression significantly decreased AB level by suppressing BACE1 expression in cells expressing human pathogenic mutant APP. Taken together, our data demonstrate that miR-186 is a potent negative regulator of BACE1 in neuronal cel
|
| Regulation Gene |
Bace1
|
| Year |
2016
|
| Pubmed ID |
26710318
|
| Title |
miR-186 is decreased in aged brain and suppresses BACE1 expression
|
| Drug |
NA
|
| Disease |
Alzheimer's disease
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|