Details
| Name | cbx7 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | WI-38 and IMR90 cells |
| Experiment Method | qPCR |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | CBX7 extends the lifespan of a wide range of normal human cells and immortalizes mouse fibroblasts by downregulating expression of the Ink4a/Arf locus.CBX7 expression is downregulated during replicative senescence and its ablation by short-hairpin RNA (s |
| Regulation Gene | ink4a/arf |
| Year | 2004 |
| Pubmed ID | 14647293 |
| Title | Polycomb CBX7 has a unifying role in cellular lifespan |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |