Details
| Name | miR-204 |
| Type | miRNA |
| Species | Mus musculus |
| Tissue | Articular cartilage |
| Experiment Method | RT-PCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Up-regulated miR-204 simultaneously targets multiple components of the sulfated proteoglycan (PG) biosynthesis pathway, effectively shutting down PG anabolism. Ectopic expression of miR-204 in joints triggers spontaneous cartilage loss and OA development, |
| Regulation Gene | PG |
| Year | 2019 |
| Pubmed ID | 30944169 |
| Title | Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development. |
| Drug | NA |
| Disease | Osteoarthritis |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |