| Name |
miR-21
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
cardiac
|
| Experiment Method |
qRT-PCR,miRNA microarray,Senescence-associated B-galactosidase staining,Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
miR-21 is upregulated in the aged heart, and suppression of miR-21 is protective against D-gal-induced cardiac alterations and Dox-induced cardiomyocyte senescence.
|
| Regulation Gene |
PTEN
|
| Year |
2018
|
| Pubmed ID |
29329959
|
| Title |
miR-21 suppression prevents cardiac alterations induced by d-galactose and doxorubicin.
|
| Drug |
doxorubicin
|
| Disease |
cardiac aging
|
| Environment Factors |
d-galactose and doxorubicin
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|