| Name |
miR-21
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
HUVEC & HDF
|
| Experiment Method |
qRT-PCR,Western Blot,Northern Blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
miR-21 was found up-regulated by replicative and stress-induced senescence, despite being described as oncogenic. Transfection of early passage endothelial cells with miR-21 resulted in lower angiogenesis, and less cell proliferation mirrored by up-regula
|
| Regulation Gene |
NA
|
| Year |
2013
|
| Pubmed ID |
23496142
|
| Title |
High levels of oncomiR-21 contribute to the senescence-induced growth arrest in normal human cells and its knock-down increases the replicative lifespan
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|