| Name |
miR-216a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
Immunofluorescent analysis, SA-B-gal staining,Real-time PCR ,western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
miR-216a was found to promote telomerase activation in macrophages by 4.5-fold (P=0.002) through the Smad3/NF-kB pathway. miR-216a also induced macrophages senescence characterized by senescence-associated-B-galactosidase activity and p53 and p16 expressi
|
| Regulation Gene |
Smad3
|
| Year |
2018
|
| Pubmed ID |
29940270
|
| Title |
MicroRNA-216a promotes M1 macrophages polarization and atherosclerosis progression by activating telomerase via the Smad3/NF-kB pathway
|
| Drug |
NA
|
| Disease |
atherosclerosis
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|