| Name |
miR-216a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
Blood vessel
|
| Experiment Method |
Senescence-associated B-galactosidase staining,luciferase reporter assay,Western blot,Real-time PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
In summary, we provided evidence for the first time that the age-progressive increase in miR-216a triggers endothelial senescence and promotes the endothelial inflammation by targeting Smad3 and leading to NF-kB signalling activation. Moreover, in aged CA
|
| Regulation Gene |
Smad3
|
| Year |
2018
|
| Pubmed ID |
29512862
|
| Title |
MicroRNA-216a induces endothelial senescence and inflammation via Smad3/IkBa pathway.
|
| Drug |
NA
|
| Disease |
CAD
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|