| Name |
miR-217
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
esophageal
|
| Experiment Method |
RNA isolation and miRNA quantification,Staining for senescence-associated B-galactosidase activity,MTT,Western blotting,Luciferase reporter assays
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
miR-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb by targeting the DNMT1 3'-UTR.
|
| Regulation Gene |
DNA methyltransferase 1 (DNMT1)
|
| Year |
2017
|
| Pubmed ID |
28380423
|
| Title |
Microrna-217 modulates human skin fibroblast senescence by directly targeting DNA methyltransferase 1.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|