| Name |
miR-221
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
lung
|
| Experiment Method |
Cell Senescence Assay,Western Blots,Quantitative Real-Time PCR
|
| Up/Down |
Down
|
| Pro/Anti |
anti
|
| Funtion Description |
In summary, increased expression of miR-221 in CDDP lung cancer cells and the induction of chemotherapy resistance in lung cancer cells by miR-221 have been demonstrated. Moreover, PTEN was indicated to be the target of miR-221 and is therefore a powerful
|
| Regulation Gene |
PTEN, Akt
|
| Year |
2018
|
| Pubmed ID |
29876362
|
| Title |
Negative Regulation of PTEN by MicroRNA-221 and Its Association with Drug Resistance and Cellular Senescence in Lung Cancer Cells.
|
| Drug |
Cisplatin
|
| Disease |
lung cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|