| Name |
miR-23a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
Western blotting,Dual luciferase reporter assay,qRT-PCR,IF,IF-FISH,ChIP,SA-B-gal assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Overexpression of miR-23a not only reduced telomere-bound TRF2 and increased telomere dysfunction-induced foci (TIFs), but also accelerated senescence of human fibroblast cells, which could be rescued by ectopically expressed TRF2.
|
| Regulation Gene |
TRF2
|
| Year |
2015
|
| Pubmed ID |
25753893
|
| Title |
Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|