| Name |
miR-24
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
anterior lens capsules
|
| Experiment Method |
RT-qPCR,Western blot,Luciferase reporter assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
The oxidative stress induced upregulation of miR-24 enhances LEC apoptosis and inhibits LEC proliferation by directly targeting p53.
|
| Regulation Gene |
p53
|
| Year |
2018
|
| Pubmed ID |
29393409
|
| Title |
miR-24-p53 pathway evoked by oxidative stress promotes lens epithelial cell apoptosis in age-related cataracts
|
| Drug |
H2O2
|
| Disease |
age-related cataract
|
| Environment Factors |
oxidation
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|