| Name |
miR-29
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
muscle
|
| Experiment Method |
Luciferase reporter assay,Immunoblotting,RT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Thus, aging-induced muscle senescence results from activation of miR-29 by Wnt-3a leading to suppressed expression of several signaling proteins (p85a, IGF-1 and B-myb) that act coordinately to impair the proliferation of MPCs contributing to muscle atrop
|
| Regulation Gene |
IGF-1,P85a,B-myb
|
| Year |
2014
|
| Pubmed ID |
24659628
|
| Title |
MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways.
|
| Drug |
NA
|
| Disease |
age-related muscle atrophy
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|