A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name miR-291a-3p
Type miRNA
Species Homo sapiens
Tissue skin
Experiment Method SA-B-gal staining,Real-time PCR,Western blot
Up/Down Down
Pro/Anti anti
Funtion Description Treatment of senescent cells with mmu-miR-291a-3p decreased senescence-associated-B-galactosidase activity, enhanced proliferative potential, and reduced mRNA and protein expression of TGFBR2, p53, and p21.
Regulation Gene TGFBR2
Year 2018
Pubmed ID 30239625
Title Embryonic stem cell-derived mmu-miR-291a-3p inhibits cellular senescence in human dermal fibroblasts through the TGF-B-receptor 2 pathway.
Drug adriamycin
Disease NA
Environment Factors ionizing radiation
Circulating NA
Variant NA
High-throughput NA