| Name |
miR-30e
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
colon
|
| Experiment Method |
senescence-associated B-galactosidase (SA-B-Gal) activity,western blotting,Luciferase reporter assay,Real-time PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Interestingly, despite suppressing procaspase-3 expression, miR-30e was unable to protect RKO colon carcinoma cells from DNA damage-induced death or to induce senescence, as miR-30e completely fails to upregulate p21 in these cells.
|
| Regulation Gene |
caspase-3
|
| Year |
2016
|
| Pubmed ID |
26895377
|
| Title |
miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
gamma-irradiated (rIR)
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|