| Name |
miR-33
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
NA
|
| Experiment Method |
quantitative RT-PCR,Senescence-associated b-galactosidase staining,Western blotting, Dual luciferase reporter assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Our data unveiled that microRNA-33 was dramatically down-regulated in senescent MEFs compared to the young MEFs, and ectopic expression of microRNA-33 promoted MEFs senescence, while knock-down of microRNA-33 exhibited a protective effect against senescen
|
| Regulation Gene |
CDK6
|
| Year |
2016
|
| Pubmed ID |
27059142
|
| Title |
MicroRNA-33 promotes the replicative senescence of mouse embryonic fibroblasts by suppressing CDK6.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|