| Name |
miR-33
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
Serum
|
| Experiment Method |
RT-PCR,Western Blot,Northern Blot
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Downregulation of ABCA1 by microRNA-33 impairs the ability of macrophages to effectively efflux intracellular cholesterol, which in turn leads to higher levels of free cholesterol within senescent macrophages. Elevated intracellular lipid polarizes older
|
| Regulation Gene |
ABCA1
|
| Year |
2013
|
| Pubmed ID |
23562078
|
| Title |
Impaired Cholesterol Efflux in Senescent Macrophages Promotes Age-Related Macular Degeneration
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
1
|
| Variant |
NA
|
| High-throughput |
NA
|