| Name |
miR-34a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
vascular
|
| Experiment Method |
quantitative reverse transcriptase polymerase chain reaction , Western blot analyses
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
miR-34a increases with age in aortas and induces vascular SMC senescence through the modulation of its target SIRT1 (sirtuin 1).
|
| Regulation Gene |
Axl,SIRT1
|
| Year |
2018
|
| Pubmed ID |
30026277
|
| Title |
miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).
|
| Drug |
NA
|
| Disease |
Vascular calcification (VC)
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|