| Name |
miR-34a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
Knee joint and caput femoris cartilage
|
| Experiment Method |
RT-PCR,B-galactosidase staining,Luciferase reporter gene assay,Western blotting
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
These findings indicate that miR-34a contributes to chondrocyte death, causing OA progression through DLL1 and modulation of the PI3K/AKT pathway.
|
| Regulation Gene |
DLL1
|
| Year |
2018
|
| Pubmed ID |
30048987
|
| Title |
MiR-34a Enhances Chondrocyte Apoptosis, Senescence and Facilitates Development of Osteoarthritis by Targeting DLL1 and Regulating PI3K/AKT Pathway.
|
| Drug |
NA
|
| Disease |
Osteoarthritis
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|