| Name |
miR-34a
|
| Type |
miRNA
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
Western blotting,Real-time PCR,Immunofluorescence labeling and image analyses,Luciferase reporter constructs and luciferase assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Furthermore, increased expression of miRs-34a & -138 in the older Tg rats, correlated with a concomitant decrease in their common anti-aging target protein SIRT1, in the brains of these animals. To delineate the mechanism of action we assessed the role of
|
| Regulation Gene |
SIRT1
|
| Year |
2017
|
| Pubmed ID |
28236278
|
| Title |
Tat-Mediated Induction of miRs-34a & -138 Promotes Astrocytic Activation via Downregulation of SIRT1: Implications for Aging in HAND.
|
| Drug |
HIV
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|