| Name |
miR-34a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
liver
|
| Experiment Method |
Immunohistochemical staining,qRT-PCR,Western blot,Luciferase reporter assay,Senescence-associated B-galactosidase (SA B-gal) assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Transient introduction of miR-34a into HCC cell lines inhibited the telomerase activity and telomere length, which induced senescence-like phenotypes and affected cellular viability. We discovered that miR-34a potently targeted c-Myc and FoxM1, both of wh
|
| Regulation Gene |
c-Myc,FoxM1
|
| Year |
2015
|
| Pubmed ID |
25686834
|
| Title |
miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway.
|
| Drug |
NA
|
| Disease |
hepatocarcinoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|