| Name |
miR-34a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
NCF-CCD-18 ;NCM ; HCT-116
|
| Experiment Method |
RT-PCR,Western Blot
|
| Up/Down |
Up
|
| Pro/Anti |
NA
|
| Funtion Description |
Irinotecan (CPT-11) is topoisomerase I inhibitor used in the treatment of disseminated colorectal cancer. In colon cancer cells it induces DNA damage which leads to cytotoxicity with ensuing apoptosis or premature senescence. Epithelial cells upregulated
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22898888
|
| Title |
Irinotecan induces senescence and apoptosis in colonic cells in vitro Emil Rudolf , Stanislav John, Miroslav Cervinka
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|