Details
| Name | miR-34a |
| Type | miRNA |
| Species | Rat Rattus |
| Tissue | Bone Marrow |
| Experiment Method | qRT-PCR,Western Blot |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | MiR-34a overexpression led to a significantly increased EPC senescence, paralleled with an 40% Sirt1 reduction. Furthermore, knockdown of Sirt1 by its siRNA resulted in diminished EPC angiogenesis and increased senescence. Finally, overexpression of miR-3 |
| Regulation Gene | Sirt1 |
| Year | 2010 |
| Pubmed ID | 20424141 |
| Title | MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1 |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |