| Name |
miR-34a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
HepG2
|
| Experiment Method |
qRT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
The nuclear bile acid receptor farnesoid X receptor (FXR) inhibits microRNA-34a (miR-34a) in the liver, which results in a positive regulation of SIRT1 levels. Activation of FXR by the synthetic agonist GW4064 decreases hepatic miR-34a levels in normal mi
|
| Regulation Gene |
SIRT1
|
| Year |
2010
|
| Pubmed ID |
20185821
|
| Title |
A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition
|
| Drug |
Nuclear Bile Acid Receptor Farnesoid X Receptor (FXR)
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|