A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name miR-34a
Type miRNA
Species Homo sapiens
Tissue TIG3 TERT/B-RAF:ER
Experiment Method qPCR
Up/Down Up
Pro/Anti Pro
Funtion Description Although members of the miR-34 family are known to be transcriptionally regulated by p53, we find that miR-34a is regulated independently of p53 during oncogene-induced senescence. Instead, upregulation of miR-34a is mediated by the ETS family transcripti
Regulation Gene BCL2;CDK6
Year 2010
Pubmed ID 19696787
Title p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA