A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name miR-34a
Type miRNA
Species Homo sapiens
Tissue CLL
Experiment Method qRT-PCR
Up/Down Up
Pro/Anti Pro
Funtion Description The replicatively senescent fibroblasts also expressed increased levels of miR-34a, a p53-induced microRNA, the antisense inhibition of which delayed the onset of replicative senescence. The siRNA (short interfering RNA)-mediated knockdown of endogenous D
Regulation Gene NA
Year 2009
Pubmed ID 19701195
Title p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA