Details
| Name | miR-34 |
| Type | miRNA |
| Species | Homo sapiens |
| Tissue | fibroblasts |
| Experiment Method | qRT-PCR,Western Blot |
| Up/Down | Up |
| Pro/Anti | NA |
| Funtion Description | We found that nutlin-3a can induce senescence in normal human fibroblasts. Nutlin-3a activated and repressed a large number of p53-dependent genes, including those encoding microRNAs. mir-34a, mir-34b, and mir-34c, which have recently been shown to be dow |
| Regulation Gene | NA |
| Year | 2009 |
| Pubmed ID | 18451145 |
| Title | Nutlin-3a Activates p53 to Both Down-regulate Inhibitor of Growth 2 and Up-regulate mir-34a, mir-34b, and mir-34c Expression, and Induce Senescence |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |