| Name |
miR-34c-5p
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
blood
|
| Experiment Method |
qPCR, Western blot analysis, Transcriptome sequencing,Luciferase assays
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Mechanistically, forced expression of miR-34-5p induced senescence in LSCs through p53-p21Cip1 11 -Cyclin-dependent kinase (CDK)/Cyclin or p53-independent CDK/Cyclin pathways. Exosome-mediated transfer of miR-34c-5p was one of the reasons for miR-34c-5p d
|
| Regulation Gene |
RAB27B
|
| Year |
2018
|
| Pubmed ID |
29479064
|
| Title |
miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.
|
| Drug |
NA
|
| Disease |
AML
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|