| Name |
miR-431
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
Lumbar disc
|
| Experiment Method |
Real-time RT-PCR, Immunoblotting,RIP,SA-B-gal staining
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
miR-431 overexpression suppressed the cell proliferation and promoted the cell senescence of NPCs, while miR-431 inhibition exerted an opposing effect ; the impact of IL-1B on NPCs could be partially eliminated by miR-431 inhibition .
|
| Regulation Gene |
GSK-3B/sfrp1
|
| Year |
2018
|
| Pubmed ID |
30251693
|
| Title |
CircSEMA4B targets miR-431 modulating IL-1B-induced degradative changes in nucleus pulposus cells in intervertebral disc degeneration via Wnt pathway
|
| Drug |
NA
|
| Disease |
intervertebral disc degeneration
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|