| Name |
miR-449a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
lung
|
| Experiment Method |
SA-b-Gal staining,qRT-PCR,Western blotting, Luciferase reporter assay
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
We found that the low expression of miR-449a was highly correlated with cancer recurrence and survival of lung cancer patients. The transient introduction of miR-449a caused cell cycle arrest and cell senescence in A549 and 95D cells. Further studies reve
|
| Regulation Gene |
E2F3
|
| Year |
2014
|
| Pubmed ID |
24211326
|
| Title |
Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells.
|
| Drug |
NA
|
| Disease |
lung cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|