| Name |
miR-449a
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
PC-3;DU-145;DuPro;DU-1.1;B5
|
| Experiment Method |
Immunoblot
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
MiR-449a suppresses Rb phosphorylation through the knockdown of Cyclin D1 and previously validated target HDAC1MicroRNA-449a is depleted in human prostate tumors and functions as a potential tumor suppressor miRNA by inhibiting proliferation and promoting
|
| Regulation Gene |
Cyclin D1;CDK6;CDC25A
|
| Year |
2010
|
| Pubmed ID |
20948989
|
| Title |
miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|