A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name miR-449a
Type miRNA
Species Mus musculus
Tissue Bone Marrow
Experiment Method qRT-PCR
Up/Down Down
Pro/Anti Anti
Funtion Description Deletion of miR-146a produces effects that appear as dysregulated inflammatory hematopoiesis, leading to a decline in the number and quality of hematopoietic stem cells (HSCs), excessive myeloproliferation, and, ultimately, to HSC exhaustion and hematopoi
Regulation Gene NA
Year 2013
Pubmed ID 23705069
Title MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA