| Name |
miR-494
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
B-Gal senescence assay,Western blot,RT-PCR,Immunofluorescence and microscopy
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Gain- and loss-of-function experiments show that miR-494 exacerbates DNA damage and drives endothelial senescence. Increase of miR-494 affects telomerase activity, activates p21, decreases pRb pathways, and diminishes angiogenic sprouting.
|
| Regulation Gene |
MRE11a,RAD50,NBN
|
| Year |
2018
|
| Pubmed ID |
29795397
|
| Title |
MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
genotoxic stress
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|