A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name miR-505
Type miRNA
Species Homo sapiens
Tissue MEF
Experiment Method qRT-PCR,Western Blot
Up/Down Up
Pro/Anti Pro
Funtion Description Decrease in LRF causes a decrease in ASF/SF2, which depends on up-regulation of miR-28 and miR-505. Alteration of each of the members of the LRF/miR-28/miR-505/ASF/SF3 axis affects MEF proliferation and the number of senescent and apoptotic cells. Consis
Regulation Gene ASF / SF2
Year 2010
Pubmed ID 20923760
Title MicroRNA (miRNA)-mediated interaction between leukemia/lymphoma-related factor (LRF) and alternative splicing factor/splicing factor 2 (ASF/SF2) affects mouse embryonic fibroblast senescence and apoptosis.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA