| Name |
miR-506
|
| Type |
miRNA
|
| Species |
Homo sapiens
|
| Tissue |
Ovarian
|
| Experiment Method |
RT-PCR,MTT,Western blot,Luciferase reporter assay,Immunohistochemical
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Ectopic overexpression of miR-506 in ovarian cancer cells was sufficient to inhibit proliferation and to promote senescence. We also demonstrated that CDK4 and CDK6 are direct targets of miR-506, and that miR-506 can inhibit CDK4/6-FOXM1 signaling, which
|
| Regulation Gene |
CDK4,CDK6
|
| Year |
2014
|
| Pubmed ID |
24604117
|
| Title |
MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer.
|
| Drug |
NA
|
| Disease |
Ovarian Cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|