| Name |
p16 INK4a
|
| Type |
promoter
|
| Species |
Homo sapiens
|
| Tissue |
human embryonic lung fibroblast cell line
|
| Experiment Method |
RNAi,Western blot,ChIP
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
GC- II is the key site for Sp1 binding and increase of Sp1 binding activity rather than protein levels contributes to the induction of p16 INK4a expression during cell aging.
|
| Regulation Gene |
p16 INK4a
|
| Year |
2007
|
| Pubmed ID |
17225865
|
| Title |
Sp1 is essential for p16 expression in human diploid fibroblasts during senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|